Genetic analysis of a malignant meningioma and associated metastases.
Acta Neurochir (Wien)
; 164(5): 1401-1405, 2022 05.
Article
en En
| MEDLINE
| ID: mdl-34981192
ABSTRACT
To identify genes altered in a highly aggressive metastatic meningioma primary as well as its metastases. Exome sequencing of a primary anaplastic meningioma and metastatic lesions in which DNA could be extracted and compared to germline DNA. Genetic analysis of the metastatic sites found 31 common mutations among the primary tumor and two metastatic sites. Additionally, genetic mutations were identified which were either infrequently (MUC3A, ALDH1A3, HOXA1) or not at all previously described in meningiomas (CASS4, CMKLR1). Exome sequencing of a metastatic meningioma and its distant metastases outside the CNS identified mutations that were not previously well described.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Meníngeas
/
Meningioma
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Acta Neurochir (Wien)
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos