Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies.

Abusukhun, Murad; Winkler, Martin S; Pöhlmann, Stefan; Moerer, Onnen; Meissner, Konrad; Tampe, Björn; Hofmann-Winkler, Heike; Bauer, Michael; Gräler, Markus H; Claus, Ralf A

Abusukhun, Murad; Winkler, Martin S; Pöhlmann, Stefan; Moerer, Onnen; Meissner, Konrad; Tampe, Björn; Hofmann-Winkler, Heike; Bauer, Michael; Gräler, Markus H; Claus, Ralf A.

Afiliación

Abusukhun M; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Winkler MS; Center for Molecular Biomedicine (CMB), Jena University Hospital, Jena, Germany.
Pöhlmann S; Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany.
Moerer O; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
Meissner K; Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany.
Tampe B; Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany.
Hofmann-Winkler H; Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany.
Bauer M; Department of Nephrology, University of Göttingen, Göttingen, Germany.
Gräler MH; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
Claus RA; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.

Front Immunol ; 12: 784989, 2021.

Article en En | MEDLINE | ID: mdl-34987511

Asunto(s)

COVID-19/metabolismo; Ceramidas/metabolismo; Transducción de Señal; Esfingomielina Fosfodiesterasa/metabolismo; Antiinflamatorios/uso terapéutico; COVID-19/virología; Ceramidas/sangre; Activación Enzimática; Membrana Eritrocítica/metabolismo; Eritrocitos/metabolismo; Ácidos Grasos/metabolismo; Humanos; Unidades de Cuidados Intensivos; Gravedad del Paciente; SARS-CoV-2/efectos de los fármacos; SARS-CoV-2/fisiología; Esfingomielina Fosfodiesterasa/sangre; Esfingomielinas/metabolismo; Tratamiento Farmacológico de COVID-19

Palabras clave

FIASMA; ceramide; drug repurposing; molecular biology of critical care; molecular markers; organ failure; sphingomyelinase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esfingomielina Fosfodiesterasa / Transducción de Señal / Ceramidas / COVID-19 Tipo de estudio: Clinical_trials / Observational_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Alemania

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