[Identification of a rare platelet-specific antigen HPA-10bw allele among ethnic Han Chinese population in Shandong].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 39(2): 231-233, 2022 Feb 10.
Article
en Zh
| MEDLINE
| ID: mdl-35076927
ABSTRACT
OBJECTIVE:
To study the polymorphism of human platelet antigen (HPA) system 10 among ethnic Han Chinese from Shandong, China so as to supplement the data of platelet donor bank in the region.METHODS:
Peripheral blood samples of platelet donors from the region were genotyped for HPA-10 alleles by PCR-sequence specific primer (PCR-SSP) and direct sequencing.RESULTS:
Among 1401 donors, a rare heterozygote carrier of HPA-10w (a+b+) was identified, which gave an allelic frequency of approximately 0.035%.CONCLUSION:
The detection of rare HPA-10bw antigen allele among ethnic Han Chinese from Shandong is useful for the diagnosis and prevention of neonatal alloimmune thrombocytopenia and post-transfusion purpura in the region.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antígenos de Plaqueta Humana
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Newborn
Idioma:
Zh
Revista:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Asunto de la revista:
GENETICA MEDICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China