Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis.

Oudaert, Inge; Satilmis, Hatice; Vlummens, Philip; De Brouwer, Wouter; Maes, Anke; Hose, Dirk; De Bruyne, Elke; Ghesquière, Bart; Vanderkerken, Karin; De Veirman, Kim; Menu, Eline

Oudaert, Inge; Satilmis, Hatice; Vlummens, Philip; De Brouwer, Wouter; Maes, Anke; Hose, Dirk; De Bruyne, Elke; Ghesquière, Bart; Vanderkerken, Karin; De Veirman, Kim; Menu, Eline.

Afiliación

Oudaert I; Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Brussels, Belgium.
Satilmis H; Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Brussels, Belgium.
Vlummens P; Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Brussels, Belgium.
De Brouwer W; Department of Clinical Hematology, Ghent University Hospital, Gent, Belgium.
Maes A; Department of Hematology, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Jette, Brussels, Belgium.
Hose D; Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Brussels, Belgium.
De Bruyne E; Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Brussels, Belgium.
Ghesquière B; Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Brussels, Belgium.
Vanderkerken K; Metabolomics Expertise Center, VIB Center for Cancer Biology (VIB-CCB) - Department of Oncology, KU Leuven, Leuven, Belgium.
De Veirman K; Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Brussels, Belgium.
Menu E; Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Brussels, Belgium.

J Exp Clin Cancer Res ; 41(1): 45, 2022 Feb 01.

Article en En | MEDLINE | ID: mdl-35105345

Asunto(s)

Antineoplásicos/uso terapéutico; Bortezomib/uso terapéutico; Mieloma Múltiple/tratamiento farmacológico; Inhibidores de la Síntesis de la Proteína/uso terapéutico; Pirrolina Carboxilato Reductasas/uso terapéutico; Animales; Antineoplásicos/farmacología; Bortezomib/farmacología; Proliferación Celular; Humanos; Ratones; Mieloma Múltiple/mortalidad; Mieloma Múltiple/patología; Inhibidores de la Síntesis de la Proteína/farmacología; Pirrolina Carboxilato Reductasas/farmacología; Análisis de Supervivencia

Palabras clave

Hypoxia; Multiple myeloma; PYCR1; Proline; Protein synthesis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirrolina Carboxilato Reductasas / Inhibidores de la Síntesis de la Proteína / Bortezomib / Mieloma Múltiple / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: J Exp Clin Cancer Res Año: 2022 Tipo del documento: Article País de afiliación: Bélgica

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