Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression.
Saudi Pharm J
; 30(2): 150-161, 2022 Feb.
Article
en En
| MEDLINE
| ID: mdl-35528850
Apoptosis; BUN, Blood urea nitrogen; Bad, Bcl-2 associated agonist of cell death; Bcl-2, B-cell lymphoma 2; Bcl-xL, B-cell lymphoma-extra large; Chloride channel-5; ClC-5, Chloride channel-5; Cr, Creatinine; FITC-BSA, Fluorescein isothiocyanate conjugate-bovine serum albumin; GFR, Glomerular filtration rate; GM, Gentamicin; Gentamicin endocytosis; H & E, Hematoxylin and eosin; HO-1, Heme oxygenase-1; KIM-1, Kidney injury molecule-1; MLK, Montelukast; Megalin; Montelukast; Nrf2, Nuclear factor erythroid 2-related factor 2; PI3K, Phosphoinositide 3-kinase
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01-internacional
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MEDLINE
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Saudi Pharm J
Año:
2022
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Article
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Egipto