Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression.

Azouz, Amany A; Hanna, Dina A; Abo-Saif, Ali A; Anwar Shehata Messiha, Basim

Azouz, Amany A; Hanna, Dina A; Abo-Saif, Ali A; Anwar Shehata Messiha, Basim.

Afiliación

Azouz AA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Hanna DA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Abo-Saif AA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
Anwar Shehata Messiha B; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.

Saudi Pharm J ; 30(2): 150-161, 2022 Feb.

Article en En | MEDLINE | ID: mdl-35528850

Palabras clave

Apoptosis; BUN, Blood urea nitrogen; Bad, Bcl-2 associated agonist of cell death; Bcl-2, B-cell lymphoma 2; Bcl-xL, B-cell lymphoma-extra large; Chloride channel-5; ClC-5, Chloride channel-5; Cr, Creatinine; FITC-BSA, Fluorescein isothiocyanate conjugate-bovine serum albumin; GFR, Glomerular filtration rate; GM, Gentamicin; Gentamicin endocytosis; H & E, Hematoxylin and eosin; HO-1, Heme oxygenase-1; KIM-1, Kidney injury molecule-1; MLK, Montelukast; Megalin; Montelukast; Nrf2, Nuclear factor erythroid 2-related factor 2; PI3K, Phosphoinositide 3-kinase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Saudi Pharm J Año: 2022 Tipo del documento: Article País de afiliación: Egipto

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