APTES, 3-aminopropyltriethoxysilane; AR, aspect ratio; AUC0‒∞, area under the curve; CMSRs, chiral mesoporous silica nanorods; CMSSs, chiral mesoporous silica nanospheres; CMSWs, chiral mesoporous silica nano-screws; CMSs, chiral mesoporous silicas nanoparticles; Cd, drug loading capacity; Chiral mesoporous silica; Cmax, maximum concentration; DAPI, 4,6-diamidino-2-phenylindole; DCM, dichloromethane; DOX, doxorubicin; EDC·HCl, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; FBS, fetal bovine serum; FITC, Fluorescein isothiocyanate; Frel, relative bioavailability; GI, gastrointestinal; Geometric topological structure; HOBT, 1-hydroxybenzotriazole; IEB, intestinal epithelium barrier; IR, infrared spectroscopy; Intestinal epithelium barrier; MRT0‒∞, mean residence time; MSNs, mesoporous silica nanoparticles; Morphology; Mß-CD, methyl-ß-cyclodextrin; N-PLA, N-palmitoyl-l-alanine; NPs, nanoparticles; Nano-screw; Oral adsorption; PBS, phosphate buffer solution; RBCs, red blood cells; RITC, rhodamine B isothiocyanate; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SBET, Specific surface area; SBF, simulated body fluid; SD, Sprague­Dawley; SGF, simulated gastric fluid; SIF, simulated intestinal fluid; TEOS, ethylsilicate; Tmax, peak time; Vt, pore volume; WBJH, pore diameter; XRD, X-ray diffractometry; nano-DDS, nano-drug delivery systems; t1/2, half-life