Circadian clocks of the kidney: function, mechanism, and regulation.
Physiol Rev
; 102(4): 1669-1701, 2022 10 01.
Article
en En
| MEDLINE
| ID: mdl-35575250
ABSTRACT
An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal processes. In this review, we summarize what is currently known regarding the function, mechanism, and regulation of kidney clocks. Additionally, the effect of extrarenal physiological processes, such as endocrine and neuronal signals, on kidney function is also reviewed. Circadian rhythms in renal function are an integral part of kidney physiology, underscoring the importance of considering time of day as a key biological variable. The field of circadian renal physiology is of tremendous relevance, but with limited physiological and mechanistic information on the kidney clocks this is an area in need of extensive investigation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Relojes Circadianos
Límite:
Humans
Idioma:
En
Revista:
Physiol Rev
Año:
2022
Tipo del documento:
Article