Recent Advances in Frontotemporal Dementia.
Can J Neurol Sci
; 50(4): 485-494, 2023 07.
Article
en En
| MEDLINE
| ID: mdl-35634749
ABSTRACT
Frontotemporal dementia (FTD) is a devastating neurodegenerative condition for which there is currently no effective treatment. Although it is much less common than Alzheimer's disease, the impact of FTD is increased by its relatively early onset and high heritability. Clinical heterogeneity and overlap with other neurodegenerative and psychiatric syndromes complicate diagnosis. However, recent advances in our understanding of the molecular basis of FTD provide a foundation for the development of much-needed biomarkers and targeted therapies. This review provides a summary of the recently revised clinical criteria for FTD, highlights diagnostic challenges, briefly summarizes recent molecular discoveries and then focuses on promising developments in biomarkers and clinical trials.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Demencia Frontotemporal
/
Enfermedad de Alzheimer
Límite:
Humans
Idioma:
En
Revista:
Can J Neurol Sci
Año:
2023
Tipo del documento:
Article
País de afiliación:
Canadá