Bayesian inference for discretely observed continuous time multi-state models.
Stat Med
; 41(19): 3789-3803, 2022 08 30.
Article
en En
| MEDLINE
| ID: mdl-35635068
ABSTRACT
Multi-state models are frequently applied to represent processes evolving through a discrete set of states. Important classes of multi-state models arise when transitions between states may depend on the time passed since entry into the current state or on the time elapsed from the start of the process. The former models are called semi-Markov while the latter are known as inhomogeneous Markov models. Inference for both the models presents computational difficulties when the process is only observed at discrete time points with no additional information about the state transitions. In fact, in both the cases, the likelihood function is not available in closed form. To obtain Bayesian inference under these two classes of models, we reconstruct the entire unobserved trajectories conditioned on the observed points via a Metropolis-Hastings algorithm. As proposal density we use that given by the nested Markov models whose conditioned trajectories can easily be drawn with the uniformization technique. The resulting inference is illustrated via simulation studies and the analysis of two benchmark datasets for multi-state models.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Algoritmos
Tipo de estudio:
Health_economic_evaluation
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Stat Med
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia