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Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy.
Shirzadi, Zahra; Yau, Wai-Ying W; Schultz, Stephanie A; Schultz, Aaron P; Scott, Matthew R; Goubran, Maged; Mojiri-Forooshani, Parisa; Joseph-Mathurin, Nelly; Kantarci, Kejal; Preboske, Greg; Wermer, Marieke J H; Jack, Clifford; Benzinger, Tammie; Taddei, Kevin; Sohrabi, Hamid R; Sperling, Reisa A; Johnson, Keith A; Bateman, Randall J; Martins, Ralph N; Greenberg, Steven M; Chhatwal, Jasmeer P.
Afiliación
  • Shirzadi Z; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Yau WW; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Schultz SA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Schultz AP; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Scott MR; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Goubran M; Physical Sciences Platform and Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
  • Mojiri-Forooshani P; Physical Sciences Platform and Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
  • Joseph-Mathurin N; Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO.
  • Kantarci K; Department of Radiology, Mayo Clinic, Rochester, MN.
  • Preboske G; Department of Radiology, Mayo Clinic, Rochester, MN.
  • Wermer MJH; Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
  • Jack C; Department of Radiology, Mayo Clinic, Rochester, MN.
  • Benzinger T; Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO.
  • Taddei K; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
  • Sohrabi HR; Centre for Healthy Ageing, Health Future Institute, Murdoch University, Murdoch, Western Australia, Australia.
  • Sperling RA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Johnson KA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Bateman RJ; Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO.
  • Martins RN; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
  • Greenberg SM; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Chhatwal JP; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Ann Neurol ; 92(3): 358-363, 2022 09.
Article en En | MEDLINE | ID: mdl-35670654
ABSTRACT
Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022;92358-363.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Angiopatía Amiloide Cerebral / Sustancia Blanca Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ann Neurol Año: 2022 Tipo del documento: Article País de afiliación: Marruecos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Angiopatía Amiloide Cerebral / Sustancia Blanca Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ann Neurol Año: 2022 Tipo del documento: Article País de afiliación: Marruecos