CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation.

Hua, Xiaoliang; Zhang, Jiong; Ge, Shengdong; Liu, Haoran; Du, Hexi; Niu, Qingsong; Chen, Xianguo; Yang, Cheng; Zhang, Li; Liang, Chaozhao

Hua, Xiaoliang; Zhang, Jiong; Ge, Shengdong; Liu, Haoran; Du, Hexi; Niu, Qingsong; Chen, Xianguo; Yang, Cheng; Zhang, Li; Liang, Chaozhao.

Afiliación

Hua X; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Zhang J; Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, China.
Ge S; The Institute of Urology, Anhui Medical University, Hefei, China.
Liu H; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Du H; Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, China.
Niu Q; The Institute of Urology, Anhui Medical University, Hefei, China.
Chen X; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yang C; Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, China.
Zhang L; The Institute of Urology, Anhui Medical University, Hefei, China.
Liang C; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Prostate ; 82(13): 1223-1236, 2022 09.

Article en En | MEDLINE | ID: mdl-35700340

Asunto(s)

Enfermedades Autoinmunes; Dolor Crónico; Prostatitis; Acetamidas; Animales; Diferenciación Celular; Modelos Animales de Enfermedad; Humanos; Inflamación; Macrófagos/patología; Masculino; Ratones; Dolor Pélvico/tratamiento farmacológico; Dolor Pélvico/etiología; Dolor Pélvico/metabolismo; Fenotipo; Prostatitis/patología; Pirimidinonas; Receptores CXCR3/genética; Receptores CXCR3/uso terapéutico

Palabras clave

AMG487; CXCR3; chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); immune; inflammation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Prostatitis / Enfermedades Autoinmunes / Dolor Crónico Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: Prostate Año: 2022 Tipo del documento: Article País de afiliación: China

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