Influenza A virus polymerase acidic protein E23G/K substitutions weaken key baloxavir drug-binding contacts with minimal impact on replication and transmission.

Jones, Jeremy C; Zagribelnyy, Bogdan; Pascua, Philippe Noriel Q; Bezrukov, Dmitry S; Barman, Subrata; Okda, Faten; Webby, Richard J; Ivanenkov, Yan A; Govorkova, Elena A

Jones, Jeremy C; Zagribelnyy, Bogdan; Pascua, Philippe Noriel Q; Bezrukov, Dmitry S; Barman, Subrata; Okda, Faten; Webby, Richard J; Ivanenkov, Yan A; Govorkova, Elena A.

Afiliación

Jones JC; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Zagribelnyy B; Department of Chemistry, Lomonosov State University, Moscow, Russian Federation.
Pascua PNQ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Bezrukov DS; Department of Chemistry, Lomonosov State University, Moscow, Russian Federation.
Barman S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Okda F; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Webby RJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Ivanenkov YA; Department of Chemistry, Lomonosov State University, Moscow, Russian Federation.
Govorkova EA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

PLoS Pathog ; 18(7): e1010698, 2022 07.

Article en En | MEDLINE | ID: mdl-35830486

Asunto(s)

Subtipo H1N1 del Virus de la Influenza A; Virus de la Influenza A; Gripe Humana; Tiepinas; Sustitución de Aminoácidos; Animales; Antivirales/farmacología; Antivirales/uso terapéutico; Dibenzotiepinas; Farmacorresistencia Viral/genética; Endonucleasas/metabolismo; Hurones; Humanos; Subtipo H1N1 del Virus de la Influenza A/metabolismo; Subtipo H3N2 del Virus de la Influenza A/genética; Subtipo H3N2 del Virus de la Influenza A/metabolismo; Virus de la Influenza A/genética; Virus de la Influenza A/metabolismo; Morfolinas; Oxazinas/farmacología; Piridinas/farmacología; Piridonas/farmacología; Tiepinas/farmacología; Triazinas; Proteínas Virales/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus de la Influenza A / Tiepinas / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A Límite: Animals / Humans Idioma: En Revista: PLoS Pathog Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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