Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-&#954;B pathways.

Zhang, Tianmeng; Dong, Zhuhua; Liu, Feixue; Pan, Enzhuang; He, Nana; Ma, Fenfen; Wang, Guanglu; Wang, Yan; Dong, Jingquan

Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways.

Zhang, Tianmeng; Dong, Zhuhua; Liu, Feixue; Pan, Enzhuang; He, Nana; Ma, Fenfen; Wang, Guanglu; Wang, Yan; Dong, Jingquan.

Afiliación

Zhang T; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China; Department of Medicine Laboratory, Department of Car
Dong Z; Deapartment of Economics and Related Studies, University of York, York, YO10 5DD, United Kingdom.
Liu F; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China.
Pan E; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China.
He N; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China.
Ma F; Department of Medicine Laboratory, Department of Cardiac Function Examination, The Second People's Hospital of Lianyungang City, Lianyungang Hospital Affiliated to Jiangsu University, The Second People's Hospital of Lianyungang Affiliated to Kangda College of Nanjing Medical University, Lianyungang,
Wang G; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China.
Wang Y; Department of Medicine Laboratory, Department of Cardiac Function Examination, The Second People's Hospital of Lianyungang City, Lianyungang Hospital Affiliated to Jiangsu University, The Second People's Hospital of Lianyungang Affiliated to Kangda College of Nanjing Medical University, Lianyungang,
Dong J; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China. Electronic address: 2018000029@jou.edu.cn.

Ecotoxicol Environ Saf ; 243: 113961, 2022 Sep 15.

Article en En | MEDLINE | ID: mdl-35969982

Asunto(s)

Carpas; FN-kappa B; Animales; Apoptosis; Barrera Hematoencefálica/metabolismo; Carpas/metabolismo; Inflamación/inducido químicamente; Inflamación/patología; Ivermectina/análogos & derivados; FN-kappa B/genética; FN-kappa B/metabolismo; Estrés Oxidativo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Avermectin; Carp; NF-κB; Neurotoxicity; PI3K/Akt

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carpas / FN-kappa B Límite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Año: 2022 Tipo del documento: Article

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