Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis.

Wei, Wen-Chi; Liaw, Chia-Ching; Tsai, Keng-Chang; Chiou, Chun-Tang; Tseng, Yu-Hwei; Chiou, Wen-Fei; Lin, Yu-Chi; Tsai, Chia-I; Lin, Chen-Shien; Lin, Chen-Sung; Liou, Kuo-Tong; Yu, I-Shing; Shen, Yuh-Chiang; Su, Yi-Chang

Wei, Wen-Chi; Liaw, Chia-Ching; Tsai, Keng-Chang; Chiou, Chun-Tang; Tseng, Yu-Hwei; Chiou, Wen-Fei; Lin, Yu-Chi; Tsai, Chia-I; Lin, Chen-Shien; Lin, Chen-Sung; Liou, Kuo-Tong; Yu, I-Shing; Shen, Yuh-Chiang; Su, Yi-Chang.

Afiliación

Wei WC; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan.
Liaw CC; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan; Department of Biochemical Science and Technology, National Chiayi University, Chiayi 600355, Taiwan.
Tsai KC; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan; Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 110301, Taiwan.
Chiou CT; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan.
Tseng YH; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan.
Chiou WF; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan.
Lin YC; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan.
Tsai CI; Department of Traditional Chinese Medicine, Taichung Veterans General Hospital, Taichung 407204, Taiwan.
Lin CS; Department of Chinese Medicine, Taipei Hospital, Ministry of Health and Welfare, New Taipei City 424033, Taiwan.
Lin CS; Division of Thoracic Surgery, Department of Surgery, Taipei Hospital, Ministry of Health and Welfare, New Taipei City 424033, Taiwan.
Liou KT; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan.
Yu IS; Laboratory Animal Center, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.
Shen YC; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan. Electronic address: yuhcs@nricm.edu.tw.
Su YC; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112026, Taiwan. Electronic address: sychang@nricm.edu.tw.

Pharmacol Res ; 184: 106424, 2022 10.

Article en En | MEDLINE | ID: mdl-36064077

Asunto(s)

Tratamiento Farmacológico de COVID-19; Lesión Pulmonar; Embolia Pulmonar; Enzima Convertidora de Angiotensina 2; Quimiocina CCL5; Citocinas; Fibrosis; Humanos; Interleucina-6/metabolismo; Interleucina-8; Lesión Pulmonar/tratamiento farmacológico; Pandemias; Fosfatidilinositol 3-Quinasas; Inhibidor 1 de Activador Plasminogénico; Proteínas Proto-Oncogénicas c-akt; Embolia Pulmonar/tratamiento farmacológico; Glicoproteína de la Espiga del Coronavirus; Receptor Toll-Like 4/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo; Factor de von Willebrand

Palabras clave

3-caffeoylquinic acid (PubChem CID: 1794427); 4-caffeoylquinic acid (PubChem CID: 9798666); 5-caffeoylquinic acid (PubChem CID: 5280633); Baicalin (PubChem CID: 64982); COVID-19; Glycyrrhizic acid (PubChem CID: 14982); NRICM102; Norwogonin 7-glucuronide (PubChem CID: 44258552); Oroxyloside (PubChem CID: 14655552); Pulmonary embolism; Pulmonary fibrosis; Quercetin 3-galactoside (PubChem CID: 5281643); Quercetin 3-glucoside (PubChem CID: 5280804); Quercetin 3-rhamnoside (PubChem CID: 5280459); Traditional Chinese medicine

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Embolia Pulmonar / Lesión Pulmonar / Tratamiento Farmacológico de COVID-19 Límite: Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Taiwán

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google