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Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications.
Gu, Junling; Geng, Kang; Guo, Man; Huang, Wei; Zhao, Tingting; Li, Xuling; Xu, You-Hua; Xu, Yong.
Afiliación
  • Gu J; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, China.
  • Geng K; Department of Endocrinology and Metabolism, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Nephropathy, Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.
  • Guo M; Department of Endocrinology, The Second People's Hospital of Yibin City-West China Yibin Hospital, Sichuan Univerity, Yibin, Sichuan, China.
  • Huang W; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, China.
  • Zhao T; Department of Endocrinology and Metabolism, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Nephropathy, Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.
  • Li X; Department of Plastic and Burn Surgery, National Key Clinical Construction Specialty, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
  • Xu YH; Department of Endocrinology and Metabolism, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Nephropathy, Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.
  • Xu Y; Department of Endocrinology and Metabolism, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Nephropathy, Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.
Evid Based Complement Alternat Med ; 2022: 5277673, 2022.
Article en En | MEDLINE | ID: mdl-36204129
ABSTRACT
Pyroptosis is an inflammatory form of programmed cell death that is dependent on inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased secretion of interleukin (IL)-1ß and IL-18. Recent studies have reported that hyperglycemia-induced cellular stress stimulates pyroptosis, and different signaling pathways have been shown to play crucial roles in regulating pyroptosis. This review summarized and discussed the molecular mechanisms, regulation, and cellular effects of pyroptosis in diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. In addition, this review aimed to provide new insights into identifying better treatments for diabetic microvascular complications.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2022 Tipo del documento: Article País de afiliación: China