Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications.
Evid Based Complement Alternat Med
; 2022: 5277673, 2022.
Article
en En
| MEDLINE
| ID: mdl-36204129
ABSTRACT
Pyroptosis is an inflammatory form of programmed cell death that is dependent on inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased secretion of interleukin (IL)-1ß and IL-18. Recent studies have reported that hyperglycemia-induced cellular stress stimulates pyroptosis, and different signaling pathways have been shown to play crucial roles in regulating pyroptosis. This review summarized and discussed the molecular mechanisms, regulation, and cellular effects of pyroptosis in diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. In addition, this review aimed to provide new insights into identifying better treatments for diabetic microvascular complications.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Evid Based Complement Alternat Med
Año:
2022
Tipo del documento:
Article
País de afiliación:
China