Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum.

Singh, Ajit Kumar; Phillips, Margaret; Alkrimi, Saleh; Tonelli, Marco; Boyson, Samuel P; Malone, Kiera L; Nix, Jay C; Glass, Karen C

Singh, Ajit Kumar; Phillips, Margaret; Alkrimi, Saleh; Tonelli, Marco; Boyson, Samuel P; Malone, Kiera L; Nix, Jay C; Glass, Karen C.

Afiliación

Singh AK; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Phillips M; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Alkrimi S; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, USA.
Tonelli M; NMRFAM and Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Boyson SP; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, USA.
Malone KL; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Nix JC; Molecular Biology Consortium, Advanced Light Source, Berkeley, CA 94720, USA.
Glass KC; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, USA. Electronic address: karen.glass@med.uvm.edu.

Int J Biol Macromol ; 223(Pt A): 316-326, 2022 Dec 31.

Article en En | MEDLINE | ID: mdl-36328269

Asunto(s)

Histonas; Plasmodium falciparum; Humanos; Histonas/metabolismo; Ligandos; Plasmodium falciparum/metabolismo; Unión Proteica; Dominios Proteicos; Acetilación; Factor de Transcripción TFIIIB/metabolismo

Palabras clave

Bromodomain (BRD); Chromatin reader domains; Epigenetics; Histones; Isothermal Titration Calorimetry (ITC); Malaria; Nuclear Magnetic Resonance (NMR); P. falciparum bromodomain-containing protein 1 (PfBDP1); Plasmodium falciparum (P. falciparum); Post-translational modifications (PTM); X-ray crystallography

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / Histonas Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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