CD73 aggravates alcohol-related liver fibrosis by promoting autophagy mediated activation of hepatic stellate cells through AMPK/AKT/mTOR signaling pathway.

Wu, Xue; Liu, Xue-Qi; Liu, Zhen-Ni; Xia, Guo-Qing; Zhu, Hong; Zhang, Meng-da; Wu, Bao-Ming; Lv, Xiong-Wen

Wu, Xue; Liu, Xue-Qi; Liu, Zhen-Ni; Xia, Guo-Qing; Zhu, Hong; Zhang, Meng-da; Wu, Bao-Ming; Lv, Xiong-Wen.

Afiliación

Wu X; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Institute for Liver Diseases of Anhui Medical
Liu XQ; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Institute for Liver Diseases of Anhui Medical
Liu ZN; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Institute for Liver Diseases of Anhui Medical
Xia GQ; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Institute for Liver Diseases of Anhui Medical
Zhu H; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Institute for Liver Diseases of Anhui Medical
Zhang MD; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Institute for Liver Diseases of Anhui Medical
Wu BM; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Institute for Liver Diseases of Anhui Medical
Lv XW; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Institute for Liver Diseases of Anhui Medical

Int Immunopharmacol ; 113(Pt A): 109229, 2022 Dec.

Article en En | MEDLINE | ID: mdl-36330907

Asunto(s)

5'-Nucleotidasa; Células Estrelladas Hepáticas; Cirrosis Hepática Alcohólica; Transducción de Señal; Animales; Ratones; Proteínas Quinasas Activadas por AMP/metabolismo; Autofagia; Etanol/metabolismo; Células Estrelladas Hepáticas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Serina-Treonina Quinasas TOR/metabolismo; 5'-Nucleotidasa/metabolismo; Cirrosis Hepática Alcohólica/patología

Palabras clave

AMPK/AKT/mTOR signaling pathway; Alcohol-related liver fibrosis; Autophagy; CD73; Hepatic stellate cells (HSCs)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / 5'-Nucleotidasa / Células Estrelladas Hepáticas / Cirrosis Hepática Alcohólica Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2022 Tipo del documento: Article

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