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Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study.
Seo, Jincheol; Lim, Kyung Seob; Jeon, Chang-Yeop; Baek, SeungHo; Yeo, Hyeon-Gu; Choi, Won Seok; Park, Sung-Hyun; Jeong, Kang Jin; Won, Jinyoung; Kim, Keonwoo; Park, Junghyung; Cho, Jiyeon; Seong, Jung Bae; Kim, Minji; Kim, Yu Gyeong; Huh, Jae-Won; Kim, Samhwan; Lim, Yong Hoon; Park, Hyung Woo; Tak, Hye Min; Heo, Man Seong; Choi, Ji-Woong; Paek, Sun Ha; Lee, Youngjeon.
Afiliación
  • Seo J; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Lim KS; Futuristic Animal Resource and Research Center, KRIBB, Daejeon 28116, Republic of Korea.
  • Jeon CY; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Baek S; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Yeo HG; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Choi WS; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
  • Park SH; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Jeong KJ; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Won J; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Kim K; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Park J; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Cho J; School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea.
  • Seong JB; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Kim M; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Kim YG; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Huh JW; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Kim S; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Lim YH; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
  • Park HW; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 28116, Republic of Korea.
  • Tak HM; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
  • Heo MS; Brain Engineering Convergence Research Center, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.
  • Choi JW; Department of Electrical Engineering and Computer Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.
  • Paek SH; Movement Disorder Center, Department of Neurosurgery, Seoul National University Hospital, Seoul 03080, Republic of Korea.
  • Lee Y; Department of Neurosurgery, Clinical Research Institute, Seoul National University Hospital, Hypoxia/Ischemia Disease Institute, Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Parkinsons Dis ; 2022: 4382145, 2022.
Article en En | MEDLINE | ID: mdl-36407681
The hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson's disease. However, there have been no studies that the contralateral distribution of MPTP via the cerebral collateral circulation is provided by both the circle of Willis (CoW) and connections of the carotid artery. To investigate whether MPTP-induced unilaterally damaged regions were determined by asymmetrical cerebral blood flow, the differential asymmetric damage of striatal subregions, and examined structural asymmetries in a circle of Willis, and blood flow velocity of the common carotid artery were observed in three monkeys that were infused with MPTP through the left internal carotid artery. Lower flow velocity in the ipsilateral common carotid artery and a higher ratio of ipsilateral middle cerebral artery diameter to anterior cerebral artery diameter resulted in unilateral damage. Additionally, the unilateral damaged monkey observed the apomorphine-induced contralateral rotation behavior and the temporary increase of plasma RANTES. Contrastively, higher flow velocity in the ipsilateral common carotid artery was observed in the bilateral damaged monkey. It is suggested that asymmetry of blood flow velocity and structural asymmetry of the circle of Willis should be taken into consideration when establishing more efficient hemiparkinsonian nonhuman primate models.

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Parkinsons Dis Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Parkinsons Dis Año: 2022 Tipo del documento: Article