A Zn-dependent structural transition of SOD1 modulates its ability to undergo phase separation.

Das, Bidisha; Roychowdhury, Sumangal; Mohanty, Priyesh; Rizuan, Azamat; Chakraborty, Joy; Mittal, Jeetain; Chattopadhyay, Krishnananda

Das, Bidisha; Roychowdhury, Sumangal; Mohanty, Priyesh; Rizuan, Azamat; Chakraborty, Joy; Mittal, Jeetain; Chattopadhyay, Krishnananda.

Afiliación

Das B; Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Roychowdhury S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Mohanty P; Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Rizuan A; Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.
Chakraborty J; Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.
Mittal J; Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Chattopadhyay K; Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.

EMBO J ; 42(2): e111185, 2023 01 16.

Article en En | MEDLINE | ID: mdl-36416085

Asunto(s)

Superóxido Dismutasa-1; Zinc; Humanos; Esclerosis Amiotrófica Lateral/enzimología; Mutación; Superóxido Dismutasa-1/química; Superóxido Dismutasa-1/genética; Zinc/química; Pliegue de Proteína

Palabras clave

SOD1; aggregation; amyotrophic lateral sclerosis (ALS); liquid-liquid phase separation (LLPS); molecular dynamics (MD) simulation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Zinc / Superóxido Dismutasa-1 Límite: Humans Idioma: En Revista: EMBO J Año: 2023 Tipo del documento: Article País de afiliación: India

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