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The future of engineered immune cell therapies.
Irvine, Darrell J; Maus, Marcela V; Mooney, David J; Wong, Wilson W.
Afiliación
  • Irvine DJ; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
  • Maus MV; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
  • Mooney DJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Wong WW; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Science ; 378(6622): 853-858, 2022 11 25.
Article en En | MEDLINE | ID: mdl-36423279
Immune cells are being engineered to recognize and respond to disease states, acting as a "living drug" when transferred into patients. Therapies based on engineered immune cells are now a clinical reality, with multiple engineered T cell therapies approved for treatment of hematologic malignancies. Ongoing preclinical and clinical studies are testing diverse strategies to modify the fate and function of immune cells for applications in cancer, infectious disease, and beyond. Here, we discuss current progress in treating human disease with immune cell therapeutics, emerging strategies for immune cell engineering, and challenges facing the field, with a particular emphasis on the treatment of cancer, where the most effort has been applied to date.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T / Neoplasias Hematológicas / Traslado Adoptivo / Ingeniería Celular Límite: Humans Idioma: En Revista: Science Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T / Neoplasias Hematológicas / Traslado Adoptivo / Ingeniería Celular Límite: Humans Idioma: En Revista: Science Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos