BRAF<sup>V600E</sup> in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis.

Laoukili, Jamila; van Schelven, Susanne; Küçükköse, Emre; Verheem, André; Goey, Kaitlyn; Koopman, Miriam; Borel Rinkes, Inne; Kranenburg, Onno

BRAF^V600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis.

Laoukili, Jamila; van Schelven, Susanne; Küçükköse, Emre; Verheem, André; Goey, Kaitlyn; Koopman, Miriam; Borel Rinkes, Inne; Kranenburg, Onno.

Afiliación

Laoukili J; Lab Translational Oncology, University Medical Center Utrecht, G04-228, PO Box 85500, 3508GA Utrecht, the Netherlands. Electronic address: j.laoukili@umcutrecht.nl.
van Schelven S; Lab Translational Oncology, University Medical Center Utrecht, G04-228, PO Box 85500, 3508GA Utrecht, the Netherlands.
Küçükköse E; Lab Translational Oncology, University Medical Center Utrecht, G04-228, PO Box 85500, 3508GA Utrecht, the Netherlands.
Verheem A; Lab Translational Oncology, University Medical Center Utrecht, G04-228, PO Box 85500, 3508GA Utrecht, the Netherlands.
Goey K; Department of Medical Oncology, University Medical Center, Utrecht University, Utrecht, the Netherlands.
Koopman M; Department of Medical Oncology, University Medical Center, Utrecht University, Utrecht, the Netherlands.
Borel Rinkes I; Lab Translational Oncology, University Medical Center Utrecht, G04-228, PO Box 85500, 3508GA Utrecht, the Netherlands.
Kranenburg O; Lab Translational Oncology, University Medical Center Utrecht, G04-228, PO Box 85500, 3508GA Utrecht, the Netherlands; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands. Electronic address: o.kranenburg@umcutrecht.nl.

Cell Rep ; 41(9): 111728, 2022 11 29.

Article en En | MEDLINE | ID: mdl-36450250

Asunto(s)

Neoplasias Colorrectales; Neoplasias Pulmonares; Humanos; Proteínas Proto-Oncogénicas B-raf/genética; Estrés Oxidativo; Glutamato-Cisteína Ligasa/genética; Glutatión; Neoplasias Pulmonares/genética; Neoplasias Colorrectales/genética

Palabras clave

BRAF(V600E); CP: Cancer; colorectal; glutathione; metastasis; metastatic organotropsim; oxidative stress

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Cell Rep Año: 2022 Tipo del documento: Article

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