N-Substituted piperidine-3-carbohydrazide-hydrazones against Alzheimer's disease: Synthesis and evaluation of cholinesterase, beta-amyloid inhibitory activity, and antioxidant capacity.

Parlar, Sulunay; Sayar, Gozde; Tarikogullari, Ayse H; Karadagli, Sumru Sozer; Alan, Elif; Sevin, Gulnur; Erciyas, Ercin; Holzgrabe, Ulrike; Alptuzun, Vildan

Parlar, Sulunay; Sayar, Gozde; Tarikogullari, Ayse H; Karadagli, Sumru Sozer; Alan, Elif; Sevin, Gulnur; Erciyas, Ercin; Holzgrabe, Ulrike; Alptuzun, Vildan.

Afiliación

Parlar S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Sayar G; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Tarikogullari AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Karadagli SS; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Alan E; Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Sevin G; Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Erciyas E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Holzgrabe U; Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, Wuerzburg, Germany.
Alptuzun V; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey.

Arch Pharm (Weinheim) ; 356(3): e2200519, 2023 Mar.

Article en En | MEDLINE | ID: mdl-36461719

Asunto(s)

Enfermedad de Alzheimer; Butirilcolinesterasa; Humanos; Butirilcolinesterasa/metabolismo; Enfermedad de Alzheimer/tratamiento farmacológico; Péptidos beta-Amiloides; Acetilcolinesterasa/metabolismo; Antioxidantes/química; Hidrazonas; Especies Reactivas de Oxígeno; Cinética; Relación Estructura-Actividad; Inhibidores de la Colinesterasa/química; Piperidinas/farmacología; Piperidinas/química; Simulación del Acoplamiento Molecular; Estructura Molecular

Palabras clave

acetylcholinesterase inhibitory; antioxidant activity; butyrylcholinesterase inhibitory; kinetic study; molecular modeling; thioflavin T test

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Butirilcolinesterasa / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 2023 Tipo del documento: Article País de afiliación: Turquía

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