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Setting national research priorities for difficult-to-treat depression in the UK between 2021-2026.
Chapman, Natalya; Browning, Michael; Baghurst, David; Hotopf, Matthew; Willis, Debbie; Haylock, Stuart; Zakaria, Sana; Speechley, Jan; Withey, James; Brooks, Edmund; Chan, Fiona; Pappa, Sofia; Geddes, John; Insole, Lisa; Mohammed, Zeid; Kessler, David; Jones, Peter B; Mansoori, Parisa.
Afiliación
  • Chapman N; National Institute for Health and Care Research Central Commissioning Facility, Twickenham, UK.
  • Browning M; Department of Psychiatry, University of Oxford, Oxford, UK.
  • Baghurst D; Oxford Health NHS Foundation Trust, Oxford, UK.
  • Hotopf M; National Institute for Health and Care Research Central Commissioning Facility, Twickenham, UK.
  • Willis D; National Institute for Health and Care Research Office for Clinical Research Infrastructure, Twickenham, UK.
  • Haylock S; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.
  • Zakaria S; South London and the Maudsley NHS Foundation Trust, London, UK.
  • Speechley J; National Institute for Health and Care Research Evaluation, Trials and Studies Coordinating Centre, Southampton, UK.
  • Withey J; National Institute for Health and Care Research Central Commissioning Facility, Twickenham, UK.
  • Brooks E; National Institute for Health and Care Research Central Commissioning Facility, Twickenham, UK.
  • Chan F; National Institute for Health and Care Research Central Commissioning Facility, Twickenham, UK.
  • Pappa S; National Institute for Health and Care Research Central Commissioning Facility, Twickenham, UK.
  • Geddes J; National Institute for Health and Care Research Central Commissioning Facility, Twickenham, UK.
  • Insole L; National Institute for Health and Care Research Central Commissioning Facility, Twickenham, UK.
  • Mohammed Z; West London NHS Trust, London, UK.
  • Kessler D; Department of Psychiatry, Imperial College London, London, UK.
  • Jones PB; Department of Psychiatry, University of Oxford, Oxford, UK.
  • Mansoori P; Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle, UK.
J Glob Health ; 12: 09004, 2022 Dec 22.
Article en En | MEDLINE | ID: mdl-36472926
ABSTRACT

Background:

Difficult-to-treat depression (DTD) presents a substantial health care challenge, with around one-third of people diagnosed with a depressive episode in the UK finding that their symptoms persist following treatment. This study aimed to identify priority research questions (RQs) that could inform the development of new and improved treatments, interventions, and support for people with DTD.

Methods:

Using an adapted Child Health and Nutrition Research Initiative (CHNRI) method, this national prioritisation exercise engaged 60 leading researchers and health care professionals in the UK, as well as 25 wider stakeholders with relevant lived experience to produce a ranked list of priority RQs in DTD. The final list of 99 distinct RQs was independently scored by 42 individuals against a list of five criteria answerability, effectiveness, impact on health, deliverability, and equity.

Results:

Highly ranked RQs covered a range of novel and existing treatments. The three highest scoring RQs included evaluation of psychological and pharmacological therapies (eg, behavioural activation, and augmentation therapies), as well as social interventions to reduce loneliness or increase support for people with DTD.

Conclusions:

This exercise identified and prioritised 99 RQs that could inform future research and funding decisions over the next five years. The results of this research could improve treatment and support for people affected by DTD. It also serves as an example of ways in which the CHNRI method can be adapted in a collaborative manner to provide a more active role for patients, carers, and health care professionals.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proyectos de Investigación Tipo de estudio: Prognostic_studies Límite: Child / Humans País/Región como asunto: Europa Idioma: En Revista: J Glob Health Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proyectos de Investigación Tipo de estudio: Prognostic_studies Límite: Child / Humans País/Región como asunto: Europa Idioma: En Revista: J Glob Health Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido