Hypothiocyanite and host-microbe interactions.
Mol Microbiol
; 119(3): 302-311, 2023 03.
Article
en En
| MEDLINE
| ID: mdl-36718113
ABSTRACT
The pseudohypohalous acid hypothiocyanite/hypothiocyanous acid (OSCN- /HOSCN) has been known to play an antimicrobial role in mammalian immunity for decades. It is a potent oxidant that kills bacteria but is non-toxic to human cells. Produced from thiocyanate (SCN- ) and hydrogen peroxide (H2 O2 ) in a variety of body sites by peroxidase enzymes, HOSCN has been explored as an agent of food preservation, pathogen killing, and even improved toothpaste. However, despite the well-recognized antibacterial role HOSCN plays in host-pathogen interactions, little is known about how bacteria sense and respond to this oxidant. In this work, we will summarize what is known and unknown about HOSCN in innate immunity and recent advances in understanding the responses that both pathogenic and non-pathogenic bacteria mount against this antimicrobial agent, highlighting studies done with three model organisms, Escherichia coli, Streptococcus spp., and Pseudomonas aeruginosa.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tiocianatos
/
Interacciones Microbiota-Huesped
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Microbiol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MICROBIOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos