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Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
Kaneshige, Atsunori; Bai, Longchuan; Wang, Mi; McEachern, Donna; Meagher, Jennifer L; Xu, Renqi; Kirchhoff, Paul D; Wen, Bo; Sun, Duxin; Stuckey, Jeanne A; Wang, Shaomeng.
Afiliación
  • Kaneshige A; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Bai L; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang M; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • McEachern D; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Meagher JL; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Xu R; Life Science Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Kirchhoff PD; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wen B; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Sun D; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Stuckey JA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang S; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
J Med Chem ; 66(4): 2717-2743, 2023 02 23.
Article en En | MEDLINE | ID: mdl-36735833
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Factor de Transcripción STAT5 Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Factor de Transcripción STAT5 Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos