Phillygenin Attenuated Colon Inflammation and Improved Intestinal Mucosal Barrier in DSS-induced Colitis Mice via TLR4/Src Mediated MAPK and NF-&#954;B Signaling Pathways.

Xue, Huan-Huan; Li, Jing-Jing; Li, Shi-Fei; Guo, Jing; Yan, Rui-Ping; Chen, Ting-Gui; Shi, Xiang-Hua; Wang, Jin-Dong; Zhang, Li-Wei

Phillygenin Attenuated Colon Inflammation and Improved Intestinal Mucosal Barrier in DSS-induced Colitis Mice via TLR4/Src Mediated MAPK and NF-κB Signaling Pathways.

Xue, Huan-Huan; Li, Jing-Jing; Li, Shi-Fei; Guo, Jing; Yan, Rui-Ping; Chen, Ting-Gui; Shi, Xiang-Hua; Wang, Jin-Dong; Zhang, Li-Wei.

Afiliación

Xue HH; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Li JJ; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Li SF; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Guo J; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Yan RP; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Chen TG; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
Shi XH; Shanxi Institute of Medicine and Life Science, Taiyuan 030006, China.
Wang JD; Shanxi Institute of Medicine and Life Science, Taiyuan 030006, China.
Zhang LW; Institute of Molecular Science, Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.

Int J Mol Sci ; 24(3)2023 Jan 23.

Article en En | MEDLINE | ID: mdl-36768559

Asunto(s)

Colitis Ulcerosa; Colitis; Animales; Ratones; Antiportadores/metabolismo; Colitis/inducido químicamente; Colitis/tratamiento farmacológico; Colitis/patología; Colitis Ulcerosa/inducido químicamente; Colitis Ulcerosa/tratamiento farmacológico; Colitis Ulcerosa/patología; Colon/patología; Sulfato de Dextran/toxicidad; Inflamación/metabolismo; Ratones Endogámicos C57BL; FN-kappa B/metabolismo; Transducción de Señal; Transportadores de Sulfato/metabolismo; Receptor Toll-Like 4/metabolismo; Genes src; Proteínas Quinasas Activadas por Mitógenos/metabolismo

Palabras clave

MAPK; NF-κB; Phillygenin; intestinal mucosal barrier; transcriptomics; tyrosine kinase Src; ulcerative colitis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Colitis Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: China

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