Probing the Mechanisms of Inhibitors Binding to Presenilin Homologue Using Molecular Dynamics Simulations.

Wang, Min; Liu, Kaifeng; Ma, Yingying; Han, Weiwei

Wang, Min; Liu, Kaifeng; Ma, Yingying; Han, Weiwei.

Afiliación

Wang M; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Liu K; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Ma Y; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Han W; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.

Molecules ; 28(5)2023 Feb 22.

Article en En | MEDLINE | ID: mdl-36903320

Asunto(s)

Enfermedad de Alzheimer; Secretasas de la Proteína Precursora del Amiloide; Humanos; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Enfermedad de Alzheimer/metabolismo; Simulación de Dinámica Molecular; Presenilina-1/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Péptidos beta-Amiloides/metabolismo

Palabras clave

Alzheimer's disease; conformational changes; inhibitors; molecular dynamics simulations; subunit presenilin 1

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China

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