Senescent Secretome of Blind Mole Rat <i>Spalax</i> Inhibits Malignant Behavior of Human Breast Cancer Cells Triggering Bystander Senescence and Targeting Inflammatory Response.

Odeh, Amani; Eddini, Hossam; Shawasha, Lujain; Chaban, Anastasia; Avivi, Aaron; Shams, Imad; Manov, Irena

Senescent Secretome of Blind Mole Rat Spalax Inhibits Malignant Behavior of Human Breast Cancer Cells Triggering Bystander Senescence and Targeting Inflammatory Response.

Odeh, Amani; Eddini, Hossam; Shawasha, Lujain; Chaban, Anastasia; Avivi, Aaron; Shams, Imad; Manov, Irena.

Afiliación

Odeh A; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Eddini H; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Shawasha L; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Chaban A; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Avivi A; Institute of Evolution, University of Haifa, 199 Aba Khoushy Avenue, Haifa 3498838, Israel.
Shams I; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Manov I; Institute of Evolution, University of Haifa, 199 Aba Khoushy Avenue, Haifa 3498838, Israel.

Int J Mol Sci ; 24(6)2023 Mar 07.

Article en En | MEDLINE | ID: mdl-36982207

Asunto(s)

Neoplasias de la Mama; Spalax; Animales; Humanos; Femenino; Ratas Topo; Neoplasias de la Mama/tratamiento farmacológico; Secretoma; Senescencia Celular; Microambiente Tumoral

Palabras clave

Spalax fibroblasts; breast cancer cells; interleukin 1 alpha (IL1α); nuclear factor κB (NF-κB); paracrine senescence; senescence-associated secretory phenotype (SASP)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Spalax Límite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Israel

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