A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D.

Terron, Heather M; Maranan, Derek S; Burgard, Luke A; LaFerla, Frank M; Lane, Shelley; Leissring, Malcolm A

Terron, Heather M; Maranan, Derek S; Burgard, Luke A; LaFerla, Frank M; Lane, Shelley; Leissring, Malcolm A.

Afiliación

Terron HM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.
Maranan DS; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.
Burgard LA; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
LaFerla FM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.
Lane S; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
Leissring MA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.

Int J Mol Sci ; 24(7)2023 Apr 04.

Article en En | MEDLINE | ID: mdl-37047718

Asunto(s)

Catepsina D; Fibroblastos; Animales; Ratones; Catepsina D/genética; Catepsina D/metabolismo; Regulación hacia Abajo/genética; Fibroblastos/metabolismo; Tetraciclina; Doxiciclina/farmacología; Elementos de Respuesta

Palabras clave

Alzheimer disease; CRISPR; Cre-Lox technology; cathepsin D; gene regulation; tetracycline regulatory element

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Catepsina D / Fibroblastos Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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