Protein Folding Stability Profiling of Colorectal Cancer Chemoresistance Identifies Functionally Relevant Biomarkers.

Quan, Baiyi; Bailey, Morgan A; Mantyh, John; Hsu, David S; Fitzgerald, Michael C

Quan, Baiyi; Bailey, Morgan A; Mantyh, John; Hsu, David S; Fitzgerald, Michael C.

Afiliación

Quan B; Department of Chemistry, Duke University, Durham, North Carolina 27708-0346, United States.
Bailey MA; Department of Chemistry, Duke University, Durham, North Carolina 27708-0346, United States.
Mantyh J; Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, United States.
Hsu DS; Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, United States.
Fitzgerald MC; Department of Chemistry, Duke University, Durham, North Carolina 27708-0346, United States.

J Proteome Res ; 22(6): 1923-1935, 2023 06 02.

Article en En | MEDLINE | ID: mdl-37126456

Asunto(s)

Neoplasias Colorrectales; Animales; Humanos; Oxaliplatino/farmacología; Oxaliplatino/uso terapéutico; Neoplasias Colorrectales/tratamiento farmacológico; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/metabolismo; Resistencia a Antineoplásicos/genética; Biomarcadores; Modelos Animales de Enfermedad; Pliegue de Proteína; Línea Celular Tumoral

Palabras clave

chemical denaturation; elongation factor 2; fatty acid synthase; limited proteolysis; mass spectrometry; oxaliplatin; thermal denaturation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Proteome Res Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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