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Spatial profiling of the microenvironment reveals low intratumoral heterogeneity and STK11-associated immune evasion in therapy-naïve lung adenocarcinomas.
Goldschmid, Hannah; Kluck, Klaus; Ball, Markus; Kirchner, Martina; Allgäuer, Michael; Winter, Hauke; Herth, Felix; Heußel, Claus-Peter; Pullamsetti, Soni Savai; Savai, Rajkumar; Yong, Timothy Tay Kwang; Schirmacher, Peter; Peters, Solange; Thomas, Michael; Christopoulos, Petros; Budczies, Jan; Stenzinger, Albrecht; Kazdal, Daniel.
Afiliación
  • Goldschmid H; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Kluck K; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Ball M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Germany.
  • Kirchner M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Allgäuer M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Winter H; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Germany; Department of Thoracic Surgery, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.
  • Herth F; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Germany; Department of Pulmonology, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.
  • Heußel CP; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Germany; Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.
  • Pullamsetti SS; Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
  • Savai R; Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany; Institute for Lung Health (ILH), Justus Liebig University, Giessen, Germany.
  • Yong TTK; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Department of Anatomical Pathology, Department of Molecular Pathology at Singapore General Hospital, Singapore.
  • Schirmacher P; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Center for Personalized Medicine Heidelberg (ZPM), Heidelberg, Germany.
  • Peters S; Oncology Department, Lausanne University Hospital, Lausanne, Switzerland.
  • Thomas M; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Germany; Department of Thoracic Oncology, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.
  • Christopoulos P; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Germany; Department of Thoracic Oncology, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.
  • Budczies J; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Stenzinger A; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: albrec
  • Kazdal D; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Germany. Electronic address: daniel.kazdal@med.uni-heidelberg.de.
Lung Cancer ; 180: 107212, 2023 06.
Article en En | MEDLINE | ID: mdl-37141769
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Evasión Inmune / Adenocarcinoma del Pulmón / Quinasas de la Proteína-Quinasa Activada por el AMP / Neoplasias Pulmonares Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Evasión Inmune / Adenocarcinoma del Pulmón / Quinasas de la Proteína-Quinasa Activada por el AMP / Neoplasias Pulmonares Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Alemania