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Neutralization escape of Omicron XBB, BR.2, and BA.2.3.20 subvariants.
Faraone, Julia N; Qu, Panke; Evans, John P; Zheng, Yi-Min; Carlin, Claire; Anghelina, Mirela; Stevens, Patrick; Fernandez, Soledad; Jones, Daniel; Lozanski, Gerard; Panchal, Ashish; Saif, Linda J; Oltz, Eugene M; Gumina, Richard J; Liu, Shan-Lu.
Afiliación
  • Faraone JN; Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA.
  • Qu P; Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
  • Evans JP; Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA.
  • Zheng YM; Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
  • Carlin C; Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH 43210, USA.
  • Anghelina M; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
  • Stevens P; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
  • Fernandez S; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
  • Jones D; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Lozanski G; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Panchal A; Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Saif LJ; Center for Food Animal Health, Animal Sciences Department, OARDC, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Wooster, OH 44691, USA; Veterinary Preventive Medicine Department, College of Veterinary Medicine, The Ohio State University, Wooster, OH 44691, USA;
  • Oltz EM; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA.
  • Gumina RJ; Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH 43210, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Physiology and Cell Biology, College o
  • Liu SL; Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA; Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210, USA; Dep
Cell Rep Med ; 4(5): 101049, 2023 05 16.
Article en En | MEDLINE | ID: mdl-37148877
New Omicron subvariants continue to emerge throughout the world. In particular, the XBB subvariant, which is a recombinant virus between BA.2.10.1.1 and BA.2.75.3.1.1.1, as well as the BA.2.3.20 and BR.2 subvariants that contain mutations distinct from BA.2 and BA.2.75, are currently increasing in proportion of variants sequenced. Here we show that antibodies induced by 3-dose mRNA booster vaccination as well as BA.1- and BA.4/5-wave infection effectively neutralize BA.2, BR.2, and BA.2.3.20 but have significantly reduced efficiency against XBB. In addition, the BA.2.3.20 subvariant exhibits enhanced infectivity in the lung-derived CaLu-3 cells and in 293T-ACE2 cells. Overall, our results demonstrate that the XBB subvariant is highly neutralization resistant, which highlights the need for continued monitoring of the immune escape and tissue tropism of emerging Omicron subvariants.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Anticuerpos Límite: Humans Idioma: En Revista: Cell Rep Med Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Anticuerpos Límite: Humans Idioma: En Revista: Cell Rep Med Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos