Relationship between mild iodine deficiency in pregnant women and thyroid function: A meta-analysis.
J Trace Elem Med Biol
; 78: 127197, 2023 Jul.
Article
en En
| MEDLINE
| ID: mdl-37209527
ABSTRACT
BACKGROUND:
Pregnant women are among the key groups in iodine nutrition evaluation. The purpose of the present study was to summarize the evidence supporting the relationship between mild iodine deficiency (UIC 100-150 µg/L) in pregnant women and levels of thyroid function tests.METHODS:
This review follows the guidelines for systematic reviews (PRISMA 2020). Three electronic databases (PubMed, Medline, and Embase) were searched for relevant publications in English on the association between mild iodine deficiency in pregnant women and thyroid function. Articles published in Chinese were searched in China's electronic databases (CNKI, WanFang, CBM, and WeiPu). Pooled effects were presented as standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals (CIs) using fixed or random effect models, respectively. This meta-analysis was registered at www.crd.york.ac.uk/prospero as CRD42019128120.RESULTS:
We summarized the results from 7 articles with 8261 participants. The overall pooled results showed that the levels of FT3, FT4, and abnormal TgAb (the antibody levels exceeded the upper limit of the reference range) were significantly increased in pregnant women with mild iodine deficiency compared to pregnant women with adequate iodine status (FT3 SMD=0.854, 95% CI 0.188, 1.520; FT4 SMD=0.550, 95% CI 0.050, 1.051; TgAb OR=1.292, 95% CI 1.095; 1.524). Subgroup analysis was carried out on the sample size, ethnicity, country, and gestation of FT3, FT4, and TSH, but no plausible factor was found. Egger's tests indicated no publication bias.The increase in FT3 and FT4, as well as TgAb levels, in pregnant women is associated with mild iodine deficiency.CONCLUSION:
Mild iodine deficiency is associated with an increase in FT3ï¼FT4 and TgAb levels in pregnant women. Mild iodine deficiency may increase the risk of thyroid dysfunction in pregnant women.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Desnutrición
/
Yodo
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Trace Elem Med Biol
Asunto de la revista:
METABOLISMO
/
SAUDE AMBIENTAL
Año:
2023
Tipo del documento:
Article