Extein residues regulate the catalytic function of Spl DnaX intein enzyme by restricting the near-attack conformations of the active-site residues.

Boral, Soumendu; Sen, Srijon; Kushwaha, Tushar; Inampudi, Krishna K; De, Soumya

Boral, Soumendu; Sen, Srijon; Kushwaha, Tushar; Inampudi, Krishna K; De, Soumya.

Afiliación

Boral S; School of Bioscience, Indian Institute of Technology Kharagpur, Kharagpur, India.
Sen S; School of Bioscience, Indian Institute of Technology Kharagpur, Kharagpur, India.
Kushwaha T; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Inampudi KK; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
De S; School of Bioscience, Indian Institute of Technology Kharagpur, Kharagpur, India.

Protein Sci ; 32(7): e4699, 2023 07.

Article en En | MEDLINE | ID: mdl-37313648

Asunto(s)

Exteínas; Inteínas; Dominio Catalítico; Empalme de Proteína; Aminoácidos

Palabras clave

molecular dynamics simulation; nucleophilic attack; reaction mechanism; sidechain rotamers; splicing reaction

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Exteínas / Inteínas Idioma: En Revista: Protein Sci Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: India

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google