Physical Exercise and Serum BDNF Levels: Accounting for the Val66Met Polymorphism in Older Adults.
Cogn Behav Neurol
; 36(4): 219-227, 2023 12 01.
Article
en En
| MEDLINE
| ID: mdl-37404130
ABSTRACT
BACKGROUND:
Brain-derived neurotrophic factor (BDNF) expression, which can be measured in blood serum, has been found to increase with aerobic exercise. The link between BDNF level, physical exercise, and genetic status (Val66Met polymorphism) has not been well researched in older adults.OBJECTIVE:
To investigate the possible link between BDNF expression, acute aerobic exercise, and the Val66Met polymorphism in older adults.METHOD:
Twenty-three healthy older adults participated in one session of acute aerobic exercise. Their serum BDNF levels were measured both at baseline and post exercise. Saliva samples were collected to identify each individual's genetic status.RESULTS:
At baseline, the individuals' mean serum BDNF level was 16.03 ng/mL (Val66Val = 15.89 ng/mL; Val66Met = 16.34 ng/mL); post exercise, the individuals' mean serum BDNF level was 16.81 ng/mL (Val66Val = 16.14 ng/mL; Val66Met = 18.34 ng/mL).CONCLUSION:
One session of acute aerobic exercise significantly increased the individuals' mean serum BDNF level. Males had higher BDNF levels than females. There was a significant interaction between gender and BDNF expression post exercise and a significant between-group effect of gender. The Val66Met carriers had a more positive response to the acute aerobic exercise compared with the Val66Val carriers, although without a significant difference between the two groups.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor Neurotrófico Derivado del Encéfalo
/
Suero
Tipo de estudio:
Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Cogn Behav Neurol
Asunto de la revista:
NEUROLOGIA
/
PSICOLOGIA
/
PSIQUIATRIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Noruega