Inhibition of Sirt2 Decreases ApoE Secretion in Astrocytes and Microglial Cells.

Chen, Yuxin; Zhou, Chunyu; Abdelhamid, Mona; Jung, Cha-Gyun; Michikawa, Makoto

Chen, Yuxin; Zhou, Chunyu; Abdelhamid, Mona; Jung, Cha-Gyun; Michikawa, Makoto.

Afiliación

Chen Y; Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
Zhou C; Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
Abdelhamid M; Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
Jung CG; Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
Michikawa M; Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.

J Biochem ; 174(5): 409-420, 2023 Oct 31.

Article en En | MEDLINE | ID: mdl-37488092

Asunto(s)

Enfermedad de Alzheimer; Sirtuina 2; Animales; Humanos; Ratones; Enfermedad de Alzheimer/genética; Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Apolipoproteínas E/genética; Apolipoproteínas E/metabolismo; Astrocitos; Encéfalo/metabolismo; Células HEK293; Ratones Transgénicos; Microglía/metabolismo; Sirtuina 2/metabolismo

Palabras clave

Alzheimer's disease; Sirt2Abbreviations: ad, Alzheimer's disease; ABCA1, ATP-binding cassette protein A1; ADAM10, A disintegrin and metalloproteinase domain-containing protein 10; Aß, Amyloid-beta; APP, Amyloid precursor protein; ApoE, Apolipoprotein E; BACE1, ß-site amyloid precursor protein cleaving enzyme 1; IDE, Insulin degrading enzyme; NEP, Neprilysin; PS1, Presenilin 1; Sirt2, Sirtuin 2; amyloid-ß; apolipoprotein E; glial cells

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sirtuina 2 / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Biochem Año: 2023 Tipo del documento: Article País de afiliación: Japón

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