Acellular collagen-glycosaminoglycan matrix promotes functional recovery in a rat model of volumetric muscle loss.
Regen Med
; 18(8): 623-633, 2023 08.
Article
en En
| MEDLINE
| ID: mdl-37491948
Volumetric muscle loss (VML) is a large injury to skeletal muscle. VML heals with scarring, little muscle regeneration, and incomplete strength recovery. The current treatment for VML involves transferring muscle from one part of the body to the injury site. However, this is limited by weakness of the donor site and incomplete recovery of muscle function. Therefore, other treatments have been developed to aid in muscle healing. One such treatment involves using three dimensional templates, known as scaffolds, to aid in muscle regeneration. Our goal is to determine whether a collagenglycosaminoglycan scaffold (CGS), which is already used for other medical purposes, can improve healing of VML injuries in rats. CGS placement in rat muscle injuries resulted in decreased scarring, increased muscle regeneration, and increased strength recovery compared with the non-CGS group.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regeneración
/
Enfermedades Musculares
Límite:
Animals
Idioma:
En
Revista:
Regen Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos