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Medication-related osteonecrosis of the jaw using periodontitis-induced rat before tooth extraction.
Park, Kyeong-Mee; Cheong, Jieun; Pang, Nan-Sim; Kim, Kee-Deog; Lee, Jung-Seok; Park, Wonse.
Afiliación
  • Park KM; Department of Advanced General Dentistry and Human Identification Research Institute, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
  • Cheong J; Department of Advanced General Dentistry, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
  • Pang NS; Department of Advanced General Dentistry, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
  • Kim KD; Department of Advanced General Dentistry and Human Identification Research Institute, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
  • Lee JS; Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
  • Park W; Department of Advanced General Dentistry and Human Identification Research Institute, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. wonse@yuhs.ac.
BMC Oral Health ; 23(1): 561, 2023 08 12.
Article en En | MEDLINE | ID: mdl-37573298
OBJECTIVE: This study aimed to investigate the occurrence of medication-related osteonecrosis of the jaw (MRONJ) after tooth extraction due to periodontitis in ovariectomized rats. METHODS: Twenty-four osteoporosis-induced rats were administered with zoledronic acid (ZA; ZA group) or saline (CONT group). In both groups, tooth extraction was performed after inducing periodontitis, and all animals were sacrificed 8-week after tooth extraction. RESULTS: Micro-CT of the tibia showed that the bone volume fraction, bone surface density, trabecular number, and bone mineral density were significantly higher in the ZA group than in the CONT group. Histologically, the proliferative zone on the growth plate was thicker in the ZA group than in the CONT group. Micro-CT of the extraction sites revealed that the bone volume fraction was significantly higher in the ZA group than in the CONT group. Radiologically, the ZA group showed partial healing and delayed healing. Histological analysis revealed normal bone healing status with completely healed epithelium in the extraction sites of the CONT group, whereas abnormal empty osteocytes in the necrotic bone and inflammatory infiltration were observed in the ZA group. CONCLUSION: The incidence of MRONJ increased in the rats administered with ZA.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Periodontitis / Conservadores de la Densidad Ósea / Osteonecrosis de los Maxilares Asociada a Difosfonatos Límite: Animals Idioma: En Revista: BMC Oral Health Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Corea del Sur

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Periodontitis / Conservadores de la Densidad Ósea / Osteonecrosis de los Maxilares Asociada a Difosfonatos Límite: Animals Idioma: En Revista: BMC Oral Health Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Corea del Sur