Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune Resistance by Regulating the Transcription of PD-L1 Through c-Myc.

Men, Xuelin; Zhu, Wei

Men, Xuelin; Zhu, Wei.

Afiliación

Men X; Department of Respiratory and Critical Care II, The Fourth People's Hospital of Jinan, Jinan, Shandong, P.R. China.
Zhu W; Department of Respiratory and Critical Care II, The Fourth People's Hospital of Jinan, Jinan, Shandong, P.R. China.

Immunol Invest ; 52(7): 815-831, 2023 Nov.

Article en En | MEDLINE | ID: mdl-37578465

1. Silencing of PLIN3 inhibited tumour growth in vivo and in vitro.2. Silencing of PLIN3 inhibited PD-L1 expression and Myc pathway in LUAD cells.3. c-Myc acted as a transcription factor of PD-L1.4. Silencing of PLIN3 exerted anti-tumour effects by regulating c-Myc/PD-L1.

Asunto(s)

Adenocarcinoma del Pulmón; Adenocarcinoma; Neoplasias Pulmonares; Humanos; Adenocarcinoma del Pulmón/genética; Antígeno B7-H1/genética; Antígeno B7-H1/metabolismo; Línea Celular Tumoral; Proliferación Celular/genética; Neoplasias Pulmonares/metabolismo; Perilipina-3

Palabras clave

Lung adenocarcinoma; Myc pathway; PD-L1; PLIN3; tumour growth

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenocarcinoma / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Immunol Invest Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article

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