Different cohort, disparate results: Selection bias is a key factor in autopsy cohorts.
Alzheimers Dement
; 20(1): 266-277, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-37592813
ABSTRACT
INTRODUCTION:
Research-oriented autopsy cohorts provide critical insights into dementia pathobiology. However, different studies sometimes report disparate findings, partially because each study has its own recruitment biases. We hypothesized that a straightforward metric, related to the percentage of research volunteers cognitively normal at recruitment, would predict other inter-cohort differences.METHODS:
The National Alzheimer's Coordinating Center (NACC) provided data on N = 7178 autopsied participants from 28 individual research centers. Research cohorts were grouped based on the proportion of participants with normal cognition at initial clinical visit.RESULTS:
Cohorts with more participants who were cognitively normal at recruitment contained more individuals who were older, female, had lower frequencies of apolipoprotein E ε4, Lewy body disease, and frontotemporal dementia, but higher rates of cerebrovascular disease. Alzheimer's disease (AD) pathology was little different between groups.DISCUSSION:
The percentage of participants recruited while cognitively normal predicted differences in findings in autopsy research cohorts. Most differences were in non-AD pathologies. HIGHLIGHTS Systematic differences exist between autopsy cohorts that serve dementia research. We propose a metric to use for gauging a research-oriented autopsy cohort. It is essential to consider the characteristics of autopsy cohorts.Palabras clave
Alzheimer's disease neuropathologic change; TAR DNA-binding protein 43; cerebrovascular; dementia with Lewy bodies; epidemiology; frontotemporal dementia; frontotemporal lobar degeneration with TDP-43; infarction; limbic-predominant age-related TDP-43 encephalopathy neuropathologic change; neuropathology; plaques; prevalence; stroke; synuclein; tangles
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos Cerebrovasculares
/
Enfermedad por Cuerpos de Lewy
/
Enfermedad de Alzheimer
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Alzheimers Dement
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos