Risk of metastasis and survival in patients undergoing different treatment strategies with T1 colonic neuroendocrine tumors.
J Endocrinol Invest
; 47(3): 671-681, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-37653287
ABSTRACT
PURPOSE:
The efficacy and safety of local excision (LE) for small (< 1â2 cm) colonic neuroendocrine tumors (NETs) is controversial due to the higher metastasis risk when compared with rectal NETs. The study aimed to evaluate the metastasis risk of T1 colonic NETs and compare patients' long-term prognosis after LE or radical surgery (RS).METHODS:
The Surveillance Epidemiology and End Results database was used to identify patients with T1 colonic NETs (2004â2015). Multivariable logistic regression was performed to assess factors associated with metastasis risk. Propensity score matching was used to balance the variables. Cancer-specific survival (CSS) and overall survival (OS) were calculated to estimate the prognosis of patients with T1N0M0 colonic NETs who underwent LE or RS.RESULTS:
Of the 610 patients with colonic NETs, 46 (7.54%) had metastasis at diagnosis. Tumor size (11-20 mm) (OR = 9.51; 95% confidence interval (CI) 4.32â21.45; P < 0.001), right colon (OR = 15.79; 95% CI 7.20â38.56; P < 0.001), submucosal infiltration (OR = 2.08; 95% CI 0.84â5.57; P = 0.125) were independent risk factors associated with metastasis. Of the 515 patients with T1N0M0 colonic NETs, the overall long-term prognosis of LE was as good as that of RS groups (after matching, 5-year CSS 97.9% vs. 94.6%, P = 0.450; 5-year OS 92.7% vs. 85.6%, P = 0.009).CONCLUSION:
Tumor size (11â20 mm) and site (right colon) are associated with metastasis in T1 colonic NETs. In the absence of metastasis, LE could be a viable option for 0â10 mm T1 colonic NETs with well/moderate differentiation in the left colon in terms of long-term survival.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tumores Neuroendocrinos
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J Endocrinol Invest
Año:
2024
Tipo del documento:
Article
País de afiliación:
China