Plasma cortisol-linked gene networks in hepatic and adipose tissues implicate corticosteroid-binding globulin in modulating tissue glucocorticoid action and cardiovascular risk.

Bankier, Sean; Wang, Lingfei; Crawford, Andrew; Morgan, Ruth A; Ruusalepp, Arno; Andrew, Ruth; Björkegren, Johan L M; Walker, Brian R; Michoel, Tom

Bankier, Sean; Wang, Lingfei; Crawford, Andrew; Morgan, Ruth A; Ruusalepp, Arno; Andrew, Ruth; Björkegren, Johan L M; Walker, Brian R; Michoel, Tom.

Afiliación

Bankier S; University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Wang L; Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.
Crawford A; Division of Genetics and Genomics, The Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Morgan RA; Division of Genetics and Genomics, The Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Ruusalepp A; University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Andrew R; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
Björkegren JLM; University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Walker BR; SRUC, The Roslin Institute, Edinburgh, United Kingdom.
Michoel T; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia.

Front Endocrinol (Lausanne) ; 14: 1186252, 2023.

Article en En | MEDLINE | ID: mdl-37745713

Asunto(s)

Enfermedades Cardiovasculares; Glucocorticoides; Transcortina; Humanos; Tejido Adiposo; Enfermedades Cardiovasculares/genética; Redes Reguladoras de Genes; Estudio de Asociación del Genoma Completo; Factores de Riesgo de Enfermedad Cardiaca; Hidrocortisona; Hígado; Receptores de Glucocorticoides/genética; Factores de Riesgo; Transcortina/genética

Palabras clave

causal inference; corticosteroid-binding globulin; cortisol; gene networks; systems genetics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transcortina / Enfermedades Cardiovasculares / Glucocorticoides Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido

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