Herpes zoster associated with stroke incidence in people living with human immunodeficiency virus: a nested case-control study.
BMC Infect Dis
; 23(1): 636, 2023 Sep 28.
Article
en En
| MEDLINE
| ID: mdl-37770849
ABSTRACT
BACKGROUND:
The incidence of stroke is increasing among younger people with human immunodeficiency virus (HIV). The burden of stroke has shifted toward the young people living with HIV, particularly in low- and middle-income countries. People infected with herpes zoster (HZ) were more likely to suffer stroke than the general population. However, the association of HZ infection with the incidence of stroke among patients with HIV remains unclear.METHODS:
A nested case-control study was conducted with patients with HIV registered in the Taiwan National Health Insurance Research Database in 2000-2017. A total of 509 stroke cases were 110 matched to 5090 non-stroke controls on age, sex, and date of first stroke diagnosis. Logistic regression models were used to estimate the odds ratio and 95% confidence intervals (CI) of stroke incidence.RESULTS:
The odds ratio of stroke was significantly higher in the HIV-infected population with HZ (adjusted odds ratio [AOR] 1.85, 95% CI 1.42-2.41). A significantly increased AOR of stroke was associated with hypertension (AOR 3.53, 95% CI 2.86-4.34), heart disease (AOR 2.32, 95% CI 1.54-3.48), chronic kidney disease (AOR 1.82, 95% CI 1.16-2.85), hepatitis C virus infection (AOR 1.49, 95% CI 1.22-1.83), hyperlipidemia (OR 1.41, 95% CI 1.12-1.78), and treatment with protease inhibitors (AOR 1.33, 95% CI 1.05-1.69).CONCLUSIONS:
Our findings suggest that HZ concurrent with HIV may increase the risk of stroke. The incidence rates of stroke were independent of common risk factors, suggesting strategies for early prevention of HZ infection among people living with HIV.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Accidente Cerebrovascular
/
Herpes Zóster
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Humans
Idioma:
En
Revista:
BMC Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2023
Tipo del documento:
Article
País de afiliación:
Taiwán