A drug-drug cocrystal and a co-amorphous form, prepared from honokiol and ligustrazine, inspired by Chinese patent medicine.
Acta Crystallogr B Struct Sci Cryst Eng Mater
; 79(Pt 6): 519-524, 2023 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-37966478
A drug-drug cocrystal created with two antithrombotic-active ingredients from herbs, honokiol (HON) and ligustrazine (TMP, 1:1), was synthesized and characterized. The structure of HON-TMP (1:1) was determined by single-crystal X-ray diffraction. Then co-amorphous HON-TMP was prepared by honey-assisted grinding, which was inspired by a grinding process for a Chinese patent medicine-Shijunzi honey pill. This co-amorphous drug-drug cocrystal (20% honey) exhibits improved solubility over HON and a significantly reduced sublimation tendency than TMP.
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Colección:
01-internacional
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MEDLINE
Asunto principal:
Cristalización
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En
Revista:
Acta Crystallogr B Struct Sci Cryst Eng Mater
Año:
2023
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Article