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Sleep disturbances as risk factors for neurodegeneration later in life.
Simmonds, Emily; Levine, Kristin S; Han, Jun; Iwaki, Hirotaka; Koretsky, Mathew J; Kuznetsov, Nicole; Faghri, Faraz; Solsberg, Caroline Warly; Schuh, Artur; Jones, Lietsel; Bandres-Ciga, Sara; Blauwendraat, Cornelis; Singleton, Andrew; Escott-Price, Valentina; Leonard, Hampton L; Nalls, Mike A.
Afiliación
  • Simmonds E; UK Dementia Research Institute (UKDRI) at Cardiff University, Cardiff, UK.
  • Levine KS; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA 20892.
  • Han J; DataTecnica LLC, Washington, DC, USA 20037.
  • Iwaki H; Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
  • Koretsky MJ; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA 20892.
  • Kuznetsov N; DataTecnica LLC, Washington, DC, USA 20037.
  • Faghri F; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA 20892.
  • Solsberg CW; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA 20892.
  • Schuh A; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA 20892.
  • Jones L; DataTecnica LLC, Washington, DC, USA 20037.
  • Bandres-Ciga S; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA 20892.
  • Blauwendraat C; DataTecnica LLC, Washington, DC, USA 20037.
  • Singleton A; Pharmaceutical Sciences and Pharmacogenomics, UCSF, San Francisco, CA, USA.
  • Escott-Price V; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
  • Leonard HL; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA 20892.
  • Nalls MA; Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
medRxiv ; 2023 Nov 09.
Article en En | MEDLINE | ID: mdl-37986827
The relationship between sleep disorders and neurodegeneration is complex and multi-faceted. Using over one million electronic health records (EHRs) from Wales, UK, and Finland, we mined biobank data to identify the relationships between sleep disorders and the subsequent manifestation of neurodegenerative diseases (NDDs) later in life. We then examined how these sleep disorders' severity impacts neurodegeneration risk. Additionally, we investigated how sleep attributed risk may compensate for the lack of genetic risk factors (i.e. a lower polygenic risk score) in NDD manifestation. We found that sleep disorders such as sleep apnea were associated with the risk of Alzheimer's disease (AD), amyotrophic lateral sclerosis, dementia, Parkinson's disease (PD), and vascular dementia in three national scale biobanks, with hazard ratios (HRs) ranging from 1.31 for PD to 5.11 for dementia. These sleep disorders imparted significant risk up to 15 years before the onset of an NDD. Cumulative number of sleep disorders in the EHRs were associated with a higher risk of neurodegeneration for dementia and vascular dementia. Sleep related risk factors were independent of genetic risk for Alzheimer's and Parkinson's, potentially compensating for low genetic risk in overall disease etiology. There is a significant multiplicative interaction regarding the combined risk of sleep disorders and Parkinson's disease. Poor sleep hygiene and sleep apnea are relatively modifiable risk factors with several treatment options, including CPAP and surgery, that could potentially reduce the risk of neurodegeneration. This is particularly interesting in how sleep related risk factors are significantly and independently enriched in manifesting NDD patients with low levels of genetic risk factors for these diseases.

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article