Multi-site microbiota alteration is a hallmark of kidney stone formation.
Microbiome
; 11(1): 263, 2023 Nov 25.
Article
en En
| MEDLINE
| ID: mdl-38007438
ABSTRACT
BACKGROUND:
Inquiry of microbiota involvement in kidney stone disease (KSD) has largely focussed on potential oxalate handling abilities by gut bacteria and the increased association with antibiotic exposure. By systematically comparing the gut, urinary, and oral microbiota of 83 stone formers (SF) and 30 healthy controls (HC), we provide a unified assessment of the bacterial contribution to KSD.RESULTS:
Amplicon and shotgun metagenomic sequencing approaches were consistent in identifying multi-site microbiota disturbances in SF relative to HC. Biomarker taxa, reduced taxonomic and functional diversity, functional replacement of core bioenergetic pathways with virulence-associated gene markers, and community network collapse defined SF, but differences between cohorts did not extend to oxalate metabolism.CONCLUSIONS:
We conclude that multi-site microbiota alteration is a hallmark of SF, and KSD treatment should consider microbial functional restoration and the avoidance of aberrant modulators such as poor diet and antibiotics where applicable to prevent stone recurrence. Video Abstract.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cálculos Renales
/
Microbiota
Límite:
Humans
Idioma:
En
Revista:
Microbiome
Año:
2023
Tipo del documento:
Article
País de afiliación:
Canadá