Effectiveness and safety of oral anticoagulant therapy in a real-world cohort with atrial fibrillation: The SIESTA-A study protocol.
PLoS One
; 18(11): e0294822, 2023.
Article
en En
| MEDLINE
| ID: mdl-38019815
ABSTRACT
INTRODUCTION:
Oral anticoagulants (OACs) are first-line drugs for stroke prevention in patients with atrial fibrillation (AF). The introduction of new lines of therapy with direct oral anticoagulants (DOACs) has led to a decreased use of vitamin K antagonists (VKAs). Comparative analyses of DOACs in clinical trials are scarce and the comparator has mostly been warfarin. Their impact on health outcomes in observational studies has not always been consistent. The aim of this study is to evaluate the effectiveness and safety of DOACs and VKAs in patients with AF using Real-World Data (RWD). METHODS ANDANALYSIS:
Population-based retrospective cohort study using RWD from actual practice. Period January 2012-December 2020. Inclusion criteria patients with AF who had not taken OACs in the previous 12 months. Exclusion criteria <40 years, with severe mitral stenosis, or valvular heart disease or aortic and/or mitral valve procedures. Data source The Andalusian Population Health Database, Spain. Outcomemeasures:
a) Effectiveness ischaemic stroke, transient ischaemic attack, systemic and pulmonary embolism, and death; b) Safety gastrointestinal and intracranial haemorrhaging; Independent variables age, sex, comorbidities, medication and health resource use, CHA2DS2-VASC, HAS-BLED, and analytical tests. Statisticalanalysis:
crude incidence analysis, survival models, Kaplan-Meier, Cox regression analysis adjusted for possible confounding and paired analysis by propensity score matching.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
/
Isquemia Encefálica
/
Accidente Cerebrovascular
Límite:
Humans
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2023
Tipo del documento:
Article
País de afiliación:
España