Stevioside attenuates bleomycin-induced pulmonary fibrosis by activating the Nrf2 pathway and inhibiting the NF-&#954;B and TGF-ß1/Smad2/3 pathways.

Hao, Wei; Yu, Ting-Ting; Zuo, Dong-Ze; Hu, Heng-Zhao; Zhou, Ping-Ping

Stevioside attenuates bleomycin-induced pulmonary fibrosis by activating the Nrf2 pathway and inhibiting the NF-κB and TGF-ß1/Smad2/3 pathways.

Hao, Wei; Yu, Ting-Ting; Zuo, Dong-Ze; Hu, Heng-Zhao; Zhou, Ping-Ping.

Afiliación

Hao W; Department of Functional Experimental Training Center, Basic Medical College, Wannan Medical College, Wuhu, China.
Yu TT; Department of Functional Experimental Training Center, Basic Medical College, Wannan Medical College, Wuhu, China.
Zuo DZ; Department of Pharmacy, Second People's Hospital of Hefei, Hefei, China.
Hu HZ; School of Anesthesiology, Wannan Medical College, Wuhu, China.
Zhou PP; Department of Physiology, Basic Medical College, Wannan Medical College, Wuhu, China.

Exp Lung Res ; 49(1): 205-219, 2023 11 20.

Article en En | MEDLINE | ID: mdl-38044666

Asunto(s)

Fibrosis Pulmonar; Ratones; Animales; Fibrosis Pulmonar/inducido químicamente; Fibrosis Pulmonar/tratamiento farmacológico; Fibrosis Pulmonar/metabolismo; FN-kappa B; Factor de Crecimiento Transformador beta1/metabolismo; Bleomicina/efectos adversos; Vimentina; Factor 2 Relacionado con NF-E2; Factor de Necrosis Tumoral alfa; Interleucina-6; Colágeno/metabolismo; Colágeno Tipo I/metabolismo; Cadherinas; Superóxido Dismutasa

Palabras clave

Stevioside; epithelial-mesenchymal transition; inflammatory response; oxidative stress; pulmonary fibrosis

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fibrosis Pulmonar Límite: Animals Idioma: En Revista: Exp Lung Res Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google