The Effects of Codon Usage on Protein Structure and Folding.
Annu Rev Biophys
; 53(1): 87-108, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38134335
ABSTRACT
The rate of protein synthesis is slower than many folding reactions and varies depending on the synonymous codons encoding the protein sequence. Synonymous codon substitutions thus have the potential to regulate cotranslational protein folding mechanisms, and a growing number of proteins have been identified with folding mechanisms sensitive to codon usage. Typically, these proteins have complex folding pathways and kinetically stable native structures. Kinetically stable proteins may fold only once over their lifetime, and thus, codon-mediated regulation of the pioneer round of protein folding can have a lasting impact. Supporting an important role for codon usage in folding, conserved patterns of codon usage appear in homologous gene families, hinting at selection. Despite these exciting developments, there remains few experimental methods capable of quantifying translation elongation rates and cotranslational folding mechanisms in the cell, which challenges the development of a predictive understanding of how biology uses codons to regulate protein folding.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Codón
/
Proteínas
/
Pliegue de Proteína
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Biophys
Asunto de la revista:
BIOFISICA
Año:
2024
Tipo del documento:
Article