Aerobic Asymmetric Allylic C-H Alkylation by Synergistic Chiral Primary Amine-Palladium-Hydroquinone Catalysis.
Chemistry
; 30(16): e202304316, 2024 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-38179799
ABSTRACT
A synergistic chiral primary amine/palladium /p-hydroquinone catalysis was developed to facilitate oxidative asymmetric allylic C-H alkylation under aerobic conditions. The ternary synergistic catalysis enables a facile allylic C-H activation and alkylation with oxygen so that stoichiometric utilization of benzoquinone can be avoided. The identified optimal catalytic system allows for terminal addition to allyl arenes with α-branched ß-ketocarbonyls to afford allylic adducts bearing all-carbon quaternary centers with high regio- and enantioselectivity. This work provides new insights for further studies on the aerobically oxidative C-H alkylation reaction.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China